Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.
Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with escape of the bacterium from the phagosome and the...
Main Authors: | Murugesan V S Rajaram, Jonathan P Butchar, Kishore V L Parsa, Thomas J Cremer, Amal Amer, Larry S Schlesinger, Susheela Tridandapani |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-11-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2775408?pdf=render |
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