Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation

Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation

Abstract Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationship studies demonstrated the importance of the aminopentyl chain, t...

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Bibliographic Details
Main Authors: Dr. Boulos Zacharie, Dr. Shaun D. Abbott, Jean‐Simon Duceppe, Dr. Lyne Gagnon, Dr. Brigitte Grouix, Lilianne Geerts, Liette Gervais, François Sarra‐Bournet, Valérie Perron, Dr. Nicole Wilb, Dr. Christopher L. Penney, Pierre Laurin
Format: Article
Language:English
Published: Wiley-VCH 2018-09-01
Series:ChemistryOpen
Subjects:
autoimmune diseases
cancer
inflammation
structure–activity relationships
triazines
Online Access:https://doi.org/10.1002/open.201800136

Internet

https://doi.org/10.1002/open.201800136

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