A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13. Known primari...

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Bibliographic Details
Main Authors: Ryan G. Snodgrass, Ekaterina Zezina, Dmitry Namgaladze, Sahil Gupta, Carlo Angioni, Gerd Geisslinger, Dieter Lütjohann, Bernhard Brüne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
macrophage
arachidonate 15-lipoxygenase
type B
lipoxygenase
chemokine
cholesterol
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01906/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01906/full

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