MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state.

MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state.

We report that a single growth factor, NM23-H1, enables serial passaging of both human ES and iPS cells in the absence of feeder cells, their conditioned media or bFGF in a fully defined xeno-free media on a novel defined, xeno-free surface. Stem cells cultured in this system show a gene expression...

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Bibliographic Details
Main Authors: Benoit J Smagghe, Andrew K Stewart, Mark G Carter, Laura M Shelton, Kyle J Bernier, Eric J Hartman, Amy K Calhoun, Vasilios M Hatziioannou, Gabriele Lillacci, Brian A Kirk, Brian A DiNardo, Kenneth S Kosik, Cynthia Bamdad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3591366?pdf=render

Internet

http://europepmc.org/articles/PMC3591366?pdf=render

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