PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression

PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis. There is an urgent need to identify new therapeutic targets and also understand the mechanism of PDAC progression that leads to aggressiveness of the disease. To find therapeutic targets, we analyzed da...

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Bibliographic Details
Main Authors: Sumit Agarwal, Balabhadrapatruni V.S.K. Chakravarthi, Hyung-Gyoon Kim, Nirzari Gupta, Kevin Hale, Sai Akshaya Hodigere Balasubramanya, Patsy G. Oliver, Dafydd G. Thomas, Isam-Eldin A. Eltoum, Donald J. Buchsbaum, Upender Manne, Sooryanarayana Varambally
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320301042

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http://www.sciencedirect.com/science/article/pii/S1936523320301042

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