Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7)

Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7)

In spinocerebellar ataxia-7 (SCA7), a polyglutamine (polyQ) expansion in the ataxin-7 protein leads to the formation of neuronal intranuclear inclusions (NIIs) and neurodegeneration. In this study, amyloid precursor-like protein 2 (APLP2) was identified as a partner protein for ataxin-7. APLP2, belo...

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Bibliographic Details
Main Authors: Junko Takahashi-Fujigasaki, Tilo Breidert, Hiroto Fujigasaki, Charles Duyckaerts, Jacques H. Camonis, Alexis Brice, Anne-Sophie Lebre
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
Spinocerebellar ataxia-7
Polyglutamine
Amyloid precursor-like protein 2
Neuronal intranuclear inclusions
Neurodegenerative disease
Caspase-3
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002755

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http://www.sciencedirect.com/science/article/pii/S0969996110002755

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