Preparation of radioactive Tay-Sachs ganglioside labeled in the sialic acid moiety

A procedure is described for the preparation of Tay-Sachs ganglioside specifically labeled in the sialic acid portion of the molecule. Rat brain gangliosides were labeled biosynthetically by the intracranial injection of N-acetyl-(3)H-D-mannosamine. Radioactive gangliosides were isolated and selecti...

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Bibliographic Details
Main Authors: E.H. Kolodny, R.O. Brady, J.M. Quirk, J.N. Kanfer
Format: Article
Language:English
Published: Elsevier 1970-03-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520430056