Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke

Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke

Stroke outcome is worsened by the infiltration of inflammatory immune cells into ischemic brains. Our recent study demonstrated that PD-L1- and to a lesser extent PD-L2-deficient mice had smaller brain infarcts and fewer brain-infiltrating cells vs. WT mice, suggesting a pathogenic role for PD-Ligan...

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Bibliographic Details
Main Authors: Sheetal eBodhankar, Yingxin eChen, Andrew eLapato, Arthur A. Vandenbark, Stephanie J Murphy, HALINA eOFFNER
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
T-cells
regulatory B cells
co-stimulatory pathway
MCAO
Programmed death ligand-1 and 2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00228/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00228/full

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