Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction

Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction

While downregulation of excitatory amino acid transporter 2 (EAAT2), the main transporter removing glutamate from the synapse, has been recognized in bipolar disorder (BD), the underlying mechanisms of downregulation have not been elucidated. BD is influenced by environmental factors, which may, via...

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Bibliographic Details
Main Authors: Yun-Fang Jia, YuBin Choi, Jennifer R. Ayers-Ringler, Joanna M. Biernacka, Jennifer R. Geske, Daniel R. Lindberg, Susan L. McElroy, Mark A. Frye, Doo-Sup Choi, Marin Veldic
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
bipolar disorder
SLC1A2 (EAAT2)
methylation
addiction
biomarkers
glutamate
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00217/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00217/full

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