An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke.

An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke.

Diabetes is a major risk factor for the development of stroke. Glucagon-like peptide-1 receptor (GLP-1R) agonists have been in clinical use for the treatment of diabetes and also been reported to be neuroprotective in ischemic stroke. The quinoxaline 6,7-dichloro-2-methylsulfonyl-3-N-tert- butylamin...

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Bibliographic Details
Main Authors: Huinan Zhang, Yunhan Liu, Shaoyu Guan, Di Qu, Ling Wang, Xinshang Wang, Xubo Li, Shimeng Zhou, Ying Zhou, Ning Wang, Jingru Meng, Xue Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4749391?pdf=render

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http://europepmc.org/articles/PMC4749391?pdf=render

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