Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.

Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.

Sirtuin (Sirt), a sensor of the cell metabolic state, regulates glucose and lipid metabolism. The aim of this study was to address whether rosiglitazone (RGZ) alters hepatic Sirt1 and whether Sirt1 and/or Sirt6 have a regulatory role in the protective effects of RGZ on hepatocyte steatosis.To invest...

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Bibliographic Details
Main Authors: Soo Jin Yang, Jung Mook Choi, Eugene Chang, Sung Woo Park, Cheol-Young Park
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4136882?pdf=render

Internet

http://europepmc.org/articles/PMC4136882?pdf=render

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