Additive Pharmacological Interaction between Cisplatin (CDDP) and Histone Deacetylase Inhibitors (HDIs) in MDA-MB-231 Triple Negative Breast Cancer (TNBC) Cells with Altered Notch1 Activity—An Isobolographic Analysis

Additive Pharmacological Interaction between Cisplatin (CDDP) and Histone Deacetylase Inhibitors (HDIs) in MDA-MB-231 Triple Negative Breast Cancer (TNBC) Cells with Altered Notch1 Activity—An Isobolographic Analysis

The aim of this study was to investigate the influence of the Notch1 activity level on the pharmacological interaction between cisplatin (CDDP) and two histone deacetylase inhibitors (HDIs)—valproic acid (VPA) and vorinostat (SAHA) in the triple negative breast cancer (TNBC) cells. Stable...

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Bibliographic Details
Main Authors: Anna Wawruszak, Jarogniew J. Luszczki, Joanna Kalafut, Karolina Okla, Marta Halasa, Adolfo Rivero-Muller, Andrzej Stepulak
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
triple negative breast cancer (TNBC)
cisplatin (CDDP)
histone deacetylase inhibitors (HDIs)
valproic acid (VPA)
vorinostat (SAHA)
isobolographic analysis
Notch1 receptor
Online Access:https://www.mdpi.com/1422-0067/20/15/3663

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https://www.mdpi.com/1422-0067/20/15/3663

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