Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation

Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation

<p>Abstract</p> <p>Background</p> <p>In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBCs). ERK1/2 is involved i...

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Bibliographic Details
Main Authors: Soderblom Erik J, Thompson J Will, Schwartz Evan A, Chiou Edward, Dubois Laura G, Moseley M Arthur, Zennadi Rahima
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Clinical Proteomics
Subjects:
Sickle cell disease
Mitogen-activated protein kinase ERK1/2
Red blood cell membrane
Label-free quantitation
Phosphoproteomics
Glycophorin A
Hemorheology
Online Access:http://www.clinicalproteomicsjournal.com/content/10/1/1

Internet

http://www.clinicalproteomicsjournal.com/content/10/1/1

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