Synthesis of 6-(Fluoromethyl)-19-norcholest-5(10)-en-3-ol, a Fluorinated Analogue of NP-59, using the Mild Fluorinating Reagent, TBAF(Pinacol)2

Synthesis of 6-(Fluoromethyl)-19-norcholest-5(10)-en-3-ol, a Fluorinated Analogue of NP-59, using the Mild Fluorinating Reagent, TBAF(Pinacol)2

Abstract For 45 years, efforts to prepare a fluorinated analogue of the scintiscanning/SPECT agent 6-(iodomethyl)-19-norcholest-5(10)-en-3-ol (NP-59) for development of a PET imaging agent have failed due to undesired elimination reactions and unexpected rearrangements observed­ while utilizing a wi...

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Bibliographic Details
Main Authors: Wade P. Winton, Allen F. Brooks, Ka Kit Wong, Peter J. H. Scott, Benjamin L. Viglianti
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2019-04-01
Series:SynOpen
Subjects:
steroids
pet
fluorination
cholesterol
adrenal
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611845

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1611845

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