Development and Successful Validation of Simple and Fast TLC Spot Tests for Determination of Kryptofix® 2.2.2 and Tetrabutylammonium in 18F-Labeled Radiopharmaceuticals

Development and Successful Validation of Simple and Fast TLC Spot Tests for Determination of Kryptofix® 2.2.2 and Tetrabutylammonium in 18F-Labeled Radiopharmaceuticals

Kryptofix® 2.2.2 (Kry) or tetrabutylammonium (TBA) are commonly used as phase transfer catalysts in 18F-radiopharmaceutical productions for positron emission tomography (PET). Due to their toxicity, quality control has to be performed before administration of the tracer to assure that limit concent...

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Bibliographic Details
Main Authors: Matthias Kuntzsch, Denis Lamparter, Nils Brüggener, Marco Müller, Gabriele J. Kienzle, Gerald Reischl
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Pharmaceuticals
Subjects:
Kryptofix® 2.2.2
tetrabutylammonium
fluorine-18
quality control
thin layer chromatography (TLC) spot test
Online Access:http://www.mdpi.com/1424-8247/7/5/621

Internet

http://www.mdpi.com/1424-8247/7/5/621

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