Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity

Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity

Acute graft- vs. -host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs monocyte-derived dendritic cell (moDC) alloactivation of T cells, yet preserves graft- vs.-leukemia (G...

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Bibliographic Details
Main Authors: Brian C. Betts, Frederick L. Locke, Elizabeth M. Sagatys, Joseph Pidala, Kelly Walton, Meghan Menges, Jordan Reff, Asim Saha, Julie Y. Djeu, John V. Kiluk, Marie C. Lee, Jongphil Kim, Chang Won Kang, Chih-Hang Anthony Tang, Jeremy Frieling, Conor C. Lynch, Alan List, Paulo C. Rodriguez, Bruce R. Blazar, Jose R. Conejo-Garcia, Juan R. Del Valle, Chih-Chi Andrew Hu, Claudio Anasetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
GvHD
GvL
er stress
XBP-1S
dendritic cell (DC)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02887/full

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