Reduction of GTP Cyclohydrolase I Feedback Regulating Protein Expression by Hydrogen Peroxide in Vascular Endothelial Cells
We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and GTPCH mRNA levels. The inhibitors of nitric oxid...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2005-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319322820 |