Dapagliflozin Mediates Plin5/PPARα Signaling Axis to Attenuate Cardiac Hypertrophy

Dapagliflozin Mediates Plin5/PPARα Signaling Axis to Attenuate Cardiac Hypertrophy

Objective: The purpose of this study was to investigate the effect of dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, on relieving cardiac hypertrophy and its potential molecular mechanism.Methods: Cardiac hypertrophy induced by abdominal aortic constriction (AAC) in mice, dapaglif...

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Bibliographic Details
Main Authors: Jing Yu, Huanhuan Zhao, Xin Qi, Liping Wei, Zihao Li, Chunpeng Li, Xiaoying Zhang, Hao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
dapagliflozin
cardiac hypertrophy
AngII
Plin5/PPARα signaling
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.730623/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.730623/full

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