Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP<sup>+</sup>-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP<sup>+</sup>-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

&#945;-Synuclein is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson&#8242;s disease and other synucleinopathies. Fatty acids partially regulate &#945;-Synuclein accumulation, and mesencephalic dopaminergic neurons highly express fatty acid-binding prote...

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Bibliographic Details
Main Authors: Ichiro Kawahata, Luc Bousset, Ronald Melki, Kohji Fukunaga
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
fatty acid-binding protein 3
α-synuclein
1-methyl-4-phenylpyridinium (mpp<sup>+</sup>)
mitochondria
synucleinopathy
parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/20/21/5358

Internet

https://www.mdpi.com/1422-0067/20/21/5358

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