Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections.

BACKGROUND: Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subunit or split flu vaccines rely exclusively on anti...

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Bibliographic Details
Main Authors: Mohammed Alsharifi, Yoichi Furuya, Timothy R Bowden, Mario Lobigs, Aulikki Koskinen, Matthias Regner, Lee Trinidad, David B Boyle, Arno Müllbacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2671162?pdf=render