Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.

BACKGROUND: The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by caspase-8 into its active form, tBid (truncated Bid), which then translocates to the mitochondria to trigger cytochrome c release and s...

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Bibliographic Details
Main Authors: François Gonzalvez, Fabrizio Pariselli, Olivier Jalmar, Pauline Dupaigne, Franck Sureau, Marc Dellinger, Eric A Hendrickson, Sophie Bernard, Patrice X Petit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2825271?pdf=render

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http://europepmc.org/articles/PMC2825271?pdf=render

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