Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents

Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents

In the current work, in continuation of our recent research, we synthesized and studied new chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) and the membrane-penetrating cation triphenylphosphonium (TPP), which are linked by alkyl groups of different lengths. Usi...

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Bibliographic Details
Main Authors: Julia A. Pavlova, Zimfira Z. Khairullina, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Inna A. Volynkina, Dmitry A. Skvortsov, Gennady I. Makarov, Etna Abad, Somay Y. Murayama, Susumu Kajiwara, Alena Paleskava, Andrey L. Konevega, Yuri N. Antonenko, Alex Lyakhovich, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antibiotics
Subjects:
chloramphenicol
alkyl(triphenyl)phosphonium
bacterial ribosome
molecular dynamics simulations
antibiotic activity
antiproliferative activity
Online Access:https://www.mdpi.com/2079-6382/10/5/489

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https://www.mdpi.com/2079-6382/10/5/489

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