PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4, Pi...

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Bibliographic Details
Main Authors: Yevgeniya A Mironova, Guy M Lenk, Jing-Ping Lin, Seung Joon Lee, Jeffery L Twiss, Ilaria Vaccari, Alessandra Bolino, Leif A Havton, Sang H Min, Charles S Abrams, Peter Shrager, Miriam H Meisler, Roman J Giger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
oligodendrocytes
optic nerve
axo-glial interaction
membrane transport
lysosome
Online Access:https://elifesciences.org/articles/13023

Internet

https://elifesciences.org/articles/13023

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