Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes

Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes

Objective: Olanzapine and Aripiprazole are widely used second-generation antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic side effects including obesity and diabetes. While the underlying mechanisms are not fully understood, these side effects are likely assoc...

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Bibliographic Details
Main Authors: Priya Dipta, Assel Sarsenbayeva, Miriam Shmuel, Francesca Forno, Jan W. Eriksson, Maria J. Pereira, Xesús M. Abalo, Martin Wabitsch, Morten Thaysen-Andersen, Boaz Tirosh
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Comprehensive Psychoneuroendocrinology
Subjects:
Adipocytes
Antipsychotics
Insulin resistance
Inflammation
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2666497621000473

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http://www.sciencedirect.com/science/article/pii/S2666497621000473

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