Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial

Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial

Abstract Background Sickle cell disease (SCD) is a genetic disorder which causes dysfunctional red blood cells (RBC) and is thought to increase requirements for folate, an essential B vitamin, due to increased RBC production and turnover in the disease. High-dose supplementation with 1–5 mg/d folic...

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Bibliographic Details
Main Authors: Brock A. Williams, Heather McCartney, Erin Adams, Angela M. Devlin, Joel Singer, Suzanne Vercauteren, John K. Wu, Crystal D. Karakochuk
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Trials
Subjects:
Sickle cell disease
Pediatrics
Nutrition
Folic acid
Micronutrient supplementation
Randomized control trial
Online Access:http://link.springer.com/article/10.1186/s13063-020-04540-7

Internet

http://link.springer.com/article/10.1186/s13063-020-04540-7

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