Polymorphism rs2395655 affects LEDGF/p75 binding activity and p21WAF1/CIP1 gene expression in esophageal squamous cell carcinoma

Polymorphism rs2395655 affects LEDGF/p75 binding activity and p21WAF1/CIP1 gene expression in esophageal squamous cell carcinoma

Abstract p21WAF1/CIP1 (p21) plays critical roles in cell‐cycle regulation and DNA repair and is transcriptionally regulated through p53‐dependent or ‐independent pathways. Bioinformatic analysis predicated one stress‐response element (STRE) implicated in single nucleotide polymorphism (SNP) rs239565...

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Bibliographic Details
Main Authors: Rong Guo, Yunan Ma, Min Zhao, Wenlong Zhang, Guo An, Baojun Chen, Yiping Song, Hui Xu, Yong Li
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
esophageal squamous cell carcinoma
lens epithelium‐derived growth factor
p21WAF1/CIP1
prognostic factor
single‐nucleotide polymorphism
Online Access:https://doi.org/10.1002/cam4.2067

Internet

https://doi.org/10.1002/cam4.2067

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