Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure. Although iron is necessary for metabolic homeostasis, it induces a programmed necrosis. Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated...

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Bibliographic Details
Main Authors: Jumpei Ito, Shigemiki Omiya, Mara-Camelia Rusu, Hiromichi Ueda, Tomokazu Murakawa, Yohei Tanada, Hajime Abe, Kazuki Nakahara, Michio Asahi, Manabu Taneike, Kazuhiko Nishida, Ajay M Shah, Kinya Otsu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
autophagy
iron
necrosis
ferritin
heart failure
Online Access:https://elifesciences.org/articles/62174

Internet

https://elifesciences.org/articles/62174

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