Structural Roles for the Juxtamembrane Linker Region and Transmembrane Region of Synaptobrevin 2 in Membrane Fusion

Structural Roles for the Juxtamembrane Linker Region and Transmembrane Region of Synaptobrevin 2 in Membrane Fusion

Formation of the trans-SNARE complex is believed to generate a force transfer to the membranes to promote membrane fusion, but the underlying mechanism remains elusive. In this study, we show that helix-breaking and/or length-increasing insertions in the juxtamembrane linker region of synaptobrevin-...

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Bibliographic Details
Main Authors: Yaru Hu, Le Zhu, Cong Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
synaptobrevin-2
SNARE complex assembly
membrane fusion
Munc18
Munc13
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.609708/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.609708/full

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