Preparation of Theophylline-Benzoic Acid Cocrystal and On-Line Monitoring of Cocrystallization Process in Solution by Raman Spectroscopy

Preparation of Theophylline-Benzoic Acid Cocrystal and On-Line Monitoring of Cocrystallization Process in Solution by Raman Spectroscopy

Pure theophylline-benzoic acid cocrystal was prepared via slurry and cooling crystallization in solution to overcome the disadvantages of existing preparation methods. The target cocrystal was characterized by powder X-ray diffraction (PXRD), thermalgravimetric analysis (TGA), differential scanning...

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Bibliographic Details
Main Authors: Yaohui Huang, Ling Zhou, Wenchao Yang, Yang Li, Yongfan Yang, Zaixiang Zhang, Chang Wang, Xia Zhang, Qiuxiang Yin
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Crystals
Subjects:
cocrystal
solution crystallization
Raman spectroscopy
on-line monitoring
cocrystal formation
Online Access:https://www.mdpi.com/2073-4352/9/7/329

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https://www.mdpi.com/2073-4352/9/7/329

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