DNA Methylation Contributes to the Differential Expression Levels of <i>Mecp2</i> in Male Mice Neurons and Astrocytes

DNA Methylation Contributes to the Differential Expression Levels of <i>Mecp2</i> in Male Mice Neurons and Astrocytes

Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), <i>MECP2</i> duplication syndrome (MDS), and autism spec...

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Bibliographic Details
Main Authors: Vichithra R.B. Liyanage, Carl O. Olson, Robby M. Zachariah, James R. Davie, Mojgan Rastegar
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
Rett syndrome
neurodevelopmental disorders
DNA methylation
epigenetics
MeCP2 isoforms
neurons
astrocytes
brain cells
Online Access:https://www.mdpi.com/1422-0067/20/8/1845

Internet

https://www.mdpi.com/1422-0067/20/8/1845

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