IL-21 Receptor Blockade Shifts the Follicular T Cell Balance and Reduces De Novo Donor-Specific Antibody Generation

IL-21 Receptor Blockade Shifts the Follicular T Cell Balance and Reduces De Novo Donor-Specific Antibody Generation

Donor-specific antibodies (DSAs) play a key role in chronic kidney allograft injury. Follicular T helper (Tfh) cells trigger the humoral alloimmune response and promote DSA generation, while T-follicular regulatory (Tfr) cells inhibit antibody production by suppressing Tfh and B cells. Interleukin (...

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Bibliographic Details
Main Authors: Yeqi Nian, Zhilei Xiong, Panpan Zhan, Zhen Wang, Yang Xu, Jianghao Wei, Jie Zhao, Yingxin Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
follicular T helper cells
T-follicular regulatory cells
IL-21
donor specific antibodies
antibody mediated rejection
chronic rejection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661580/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.661580/full

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