Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model

Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model

In actinobacteria, Lsr2-like nucleoid-associated proteins function as xenogeneic silencers (XS) of horizontally acquired genomic regions, including viral elements, virulence gene clusters in Mycobacterium tuberculosis, and genes involved in cryptic specialized metabolism in Streptomyces species. Con...

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Bibliographic Details
Main Authors: Johanna Wiechert, Andrei Filipchyk, Max Hünnefeld, Cornelia Gätgens, Jannis Brehm, Ralf Heermann, Julia Frunzke
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
at-rich dna
lsr2
actinobacteria
counter-silencing
horizontal gene transfer
regulatory networks
xenogeneic silencing
Online Access:https://doi.org/10.1128/mBio.02273-19

Internet

https://doi.org/10.1128/mBio.02273-19

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