Transamidation Down-Regulates Intestinal Immunity of Recombinant α-Gliadin in HLA-DQ8 Transgenic Mice

Transamidation Down-Regulates Intestinal Immunity of Recombinant α-Gliadin in HLA-DQ8 Transgenic Mice

Enzymatic transamidation of gliadins by microbial transglutaminase (mTG) inhibits interferon-γ (IFN-γ) secretion by intestinal T cell lines in patients with celiac disease (CD). To gain insight into the cellular mechanisms underlying the down-regulatory effects of transamidation, we tested a single...

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Bibliographic Details
Main Authors: Stefano Rossi, Deborah Giordano, Maria Fiorella Mazzeo, Francesco Maurano, Diomira Luongo, Angelo Facchiano, Rosa Anna Siciliano, Mauro Rossi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
celiac disease
HLA-DQ8
immunomodulation
in silico analysis
mass spectrometry
recombinant alpha gliadin
Online Access:https://www.mdpi.com/1422-0067/22/13/7019

Internet

https://www.mdpi.com/1422-0067/22/13/7019

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