Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates

Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates

Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body’s first-pass metabol...

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Bibliographic Details
Main Authors: Wilson Poh, Nurlilah Ab Rahman, Yan Ostrovski, Josué Sznitman, Kevin Pethe, Say Chye Joachim Loo
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
pulmonary drug delivery
tuberculosis
superparamagnetic iron oxides
solvent emulsion
computational fluid dynamics
nanoparticle aggregates
Online Access:http://dx.doi.org/10.1080/10717544.2019.1676841

Internet

http://dx.doi.org/10.1080/10717544.2019.1676841

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