Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman

General and stereoselective synthesis of tetracyclic isochroman-containing polyketide oligomers is challenging. Here, the authors report on an Au(I)/chiral Sc(III) bimetallic catalyst for a biomimetic asymmetric hetero-Diels–Alder reaction for in-situ generation of isochromene and ortho-quinonemethi...

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Main Authors:	Xiangfeng Lin, Xianghui Liu, Kai Wang, Qian Li, Yan Liu, Can Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25198-y

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spelling	doaj-d8067b9568c34fa380fcc342497aa73e2021-08-22T11:40:27ZengNature Publishing GroupNature Communications2041-17232021-08-011211910.1038/s41467-021-25198-yBiomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochromanXiangfeng Lin0Xianghui Liu1Kai Wang2Qian Li3Yan Liu4Can Li5State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesState Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of SciencesGeneral and stereoselective synthesis of tetracyclic isochroman-containing polyketide oligomers is challenging. Here, the authors report on an Au(I)/chiral Sc(III) bimetallic catalyst for a biomimetic asymmetric hetero-Diels–Alder reaction for in-situ generation of isochromene and ortho-quinonemethide.https://doi.org/10.1038/s41467-021-25198-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiangfeng Lin Xianghui Liu Kai Wang Qian Li Yan Liu Can Li
spellingShingle	Xiangfeng Lin Xianghui Liu Kai Wang Qian Li Yan Liu Can Li Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman Nature Communications
author_facet	Xiangfeng Lin Xianghui Liu Kai Wang Qian Li Yan Liu Can Li
author_sort	Xiangfeng Lin
title	Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
title_short	Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
title_full	Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
title_fullStr	Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
title_full_unstemmed	Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
title_sort	biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	General and stereoselective synthesis of tetracyclic isochroman-containing polyketide oligomers is challenging. Here, the authors report on an Au(I)/chiral Sc(III) bimetallic catalyst for a biomimetic asymmetric hetero-Diels–Alder reaction for in-situ generation of isochromene and ortho-quinonemethide.
url	https://doi.org/10.1038/s41467-021-25198-y
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Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman

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