Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease

Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease

Background: Dysfunctions of the ubiquitin proteasome system (UPS), including the highly abundant neuronal enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and autophagy-related changes (lysosomal degradation) are implicated in several neurodegenerative disorders including Alzheimer's d...

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Bibliographic Details
Main Authors: Annika Öhrfelt, Per Johansson, Anders Wallin, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Johan Svensson
Format: Article
Language:English
Published: Karger Publishers 2016-07-01
Series:Dementia and Geriatric Cognitive Disorders Extra
Subjects:
Alzheimer’s disease
Biomarkers
Cerebrospinal fluid
DJ-1
Neuron-specific enolase
Ubiquitin carboxyl-terminal hydrolase L1
Tau phosphorylated at threonine 231
Online Access:http://www.karger.com/Article/FullText/447239

Internet

http://www.karger.com/Article/FullText/447239

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