hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression

hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression

Summary In non-small cell lung cancer cell lines, activation of β-catenin independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differentiation. miRNA expression profiling on a human lung a...

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Bibliographic Details
Main Authors: Sreedevi Avasarala, Michelle Van Scoyk, Jianbin Wang, Marybeth Sechler, Katherine Vandervest, Christine Brzezinski, Colin Weekes, Michael G. Edwards, John Arcaroli, Richard E. Davis, Rama Kamesh Bikkavilli, Robert A. Winn
Format: Article
Language:English
Published: The Company of Biologists 2013-05-01
Series:Biology Open
Subjects:
Frizzled 9
MDM2
Non-small cell lung cancer
p53
Wnt7a
hsa-miR29b
Online Access:http://bio.biologists.org/content/2/7/675

Internet

http://bio.biologists.org/content/2/7/675

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