Prokaryotic Genome Expansion Is Facilitated by Phages and Plasmids but Impaired by CRISPR

Viruses and plasmids can introduce novel DNA into bacterial cells, thereby creating an opportunity for genome expansion; conversely, CRISPR, the prokaryotic adaptive immune system, which targets and eliminates foreign DNAs, may impair genome expansions. Recent studies presented conflicting results o...

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Bibliographic Details
Main Authors: Na L. Gao, Jingchao Chen, Teng Wang, Martin J. Lercher, Wei-Hua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02254/full