Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.

Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.

BACKGROUND: Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases. We ascertained in vitro whether pancreatic adenoc...

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Bibliographic Details
Main Authors: Daniela Basso, Paola Fogar, Massimo Falconi, Elisa Fadi, Cosimo Sperti, Chiara Frasson, Eliana Greco, Domenico Tamburrino, Sara Teolato, Stefania Moz, Dania Bozzato, Michela Pelloso, Andrea Padoan, Giuseppe De Franchis, Elisa Gnatta, Monica Facco, Carlo-Federico Zambon, Filippo Navaglia, Claudio Pasquali, Giuseppe Basso, Gianpietro Semenzato, Sergio Pedrazzoli, Paolo Pederzoli, Mario Plebani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554636?pdf=render

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http://europepmc.org/articles/PMC3554636?pdf=render

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