Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines

Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines

Incidents of breast cancer (BC) are on the rise on a daily basis and have proven to be the most prevelant cause of death for women in both developed and developing countries. Among total BC cases diagnosed after menopause, 70% of cases are Estrogen Receptor (ER) positive (ER-positive or ER+). Mutati...

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Bibliographic Details
Main Authors: Abbas Khan, Ashfaq-Ur-Rehman, Muhammad Junaid, Cheng-Dong Li, Shoaib Saleem, Fahad Humayun, Shazia Shamas, Syed Shujait Ali, Zainib Babar, Dong-Qing Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
ESR1 estrogen receptor
mutation
resistance
simulation
molecular docking
molecular dynamics (MD) simulation
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00159/full

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https://www.frontiersin.org/article/10.3389/fmolb.2019.00159/full

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