YAP controls retinal stem cell DNA replication timing and genomic stability

YAP controls retinal stem cell DNA replication timing and genomic stability

The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal...

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Bibliographic Details
Main Authors: Pauline Cabochette, Guillermo Vega-Lopez, Juliette Bitard, Karine Parain, Romain Chemouny, Christel Masson, Caroline Borday, Marie Hedderich, Kristine A Henningfeld, Morgane Locker, Odile Bronchain, Muriel Perron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
retina
neural stem cell
Hippo/Yap pathway
cell proliferation
ciliary marginal zone
Online Access:https://elifesciences.org/articles/08488

Internet

https://elifesciences.org/articles/08488

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