A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease

A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease

BackgroundChagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A, or...

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Main Authors: Alexandra Gomes dos Santos, Elieser Hitoshi Watanabe, Daiane Tomomi Ferreira, Jamille Oliveira, Érika Shimoda Nakanishi, Claudia Silva Oliveira, Edimar Bocchi, Cristina Terra Gallafrio Novaes, Fatima Cruz, Noemia Barbosa Carvalho, Paula Keiko Sato, Edite Hatsumi Yamashiro-Kanashiro, Alessandra Pontillo, Vera Lucia Teixeira de Freitas, Luiz Fernando Onuchic, Maria Aparecida Shikanai-Yasuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
T. cruzi parasitemia
cardiomyopathy
Chagas disease
HIV
IL1 B
IL6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.521409/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.521409/full

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