Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder involving progressive motor disturbances, cognitive decline, and desynchronized sleep–wake rhythms. Recent studies revealed that restoring normal sleep–wake cycles can improve cognitive function in HD mice, suggesting that some sleep/wak...

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Bibliographic Details
Main Authors: Rhîannan H. Williams, A. Jennifer Morton, Denis Burdakov
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Hypocretin
Orexin
Hypothalamus
Sleep
Reward
Huntington's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100060X

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http://www.sciencedirect.com/science/article/pii/S096999611100060X

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