The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The capacity of α-mangostin (α-MG) and β-mangostin (β-MG) from mangosteen pericarp on P-glycoprotein (Pgp) in silico, in vitro, and ex vivo was investigated in this study. Screening with the ADMET Predictor™ program predicted the two compounds to be both a Pgp inhibitor and Pgp substrate. The compou...

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Bibliographic Details
Main Authors: Panudda Dechwongya, Songpol Limpisood, Nawong Boonnak, Supachoke Mangmool, Mariko Takeda-Morishita, Thitianan Kulsirirat, Pattarawit Rukthong, Korbtham Sathirakul
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
xanthones
mangosteen pericarp
P-glycoprotein
caco-2 cell
bidirectional transport
<i>MDR1</i> expression
Online Access:https://www.mdpi.com/1420-3049/25/24/5877

Internet

https://www.mdpi.com/1420-3049/25/24/5877

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