In Silico Prediction of O<sup>6</sup>-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods

In Silico Prediction of O<sup>6</sup>-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods

O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT), a unique DNA repair enzyme, can confer resistance to DNA anticancer alkylating agents that modify the O<sup>6</sup>-position of guanine. Thus, inhibition of MGMT activity in tumors has a great interest for cancer resea...

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Bibliographic Details
Main Authors: Guohui Sun, Tengjiao Fan, Xiaodong Sun, Yuxing Hao, Xin Cui, Lijiao Zhao, Ting Ren, Yue Zhou, Rugang Zhong, Yongzhen Peng
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
MGMT
anticancer alkylating agents
resistance
inhibitors
QSAR
classification
Online Access:https://www.mdpi.com/1420-3049/23/11/2892

Internet

https://www.mdpi.com/1420-3049/23/11/2892

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