Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP<sup>4+</sup>, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H<sub>2</sub>O)MnTnHex-2-PyP<sup>5+</sup>

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP<sup>4+</sup>, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H<sub>2</sub>O)MnTnHex-2-PyP<sup>5+</sup>

Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, (H<sub>2</sub>O)MnTnHex-2-PyP<sup>5+</sup> (MnHex) carrying long hexyl chains, is a lipophilic mimic of superoxide dismutase (SOD) and a redox-active drug candidate. MnHex crosses the blood–brain barrier, and improved...

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Bibliographic Details
Main Authors: Litao Li, Artak Tovmasyan, Huaxin Sheng, Bin Xu, Romulo S. Sampaio, Julio S. Reboucas, David S. Warner, Ines Batinic-Haberle, Ivan Spasojevic
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
MnTnHex-2-PyP5+
FeTnHex-2-PyP5+
SOD mimics
pharmacokinetics
rodent middle cerebral artery occlusion
MCAO
Online Access:https://www.mdpi.com/2076-3921/9/6/467

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https://www.mdpi.com/2076-3921/9/6/467

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