Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge

Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge

As viruses continue to mutate the need for rapid high titer neutralizing antibody responses has been highlighted. To meet these emerging threats, agents that enhance vaccine adjuvant activity are needed that are safe with minimal local or systemic side effects. To respond to this demand, we sought s...

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Bibliographic Details
Main Authors: Tetsuya Saito, Yukiya Sako, Fumi Sato-Kaneko, Tadashi Hosoya, Shiyin Yao, Fitzgerald S. Lao, Jonathan Shpigelman, Karen Messer, Minya Pu, Nikunj M. Shukla, Michael Chan, Paul J. Chu, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Maripat Corr
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
vaccine
adjuvant
influenza virus
Toll-like receptor4
monophosphoryl lipid A, NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701445/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.701445/full

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