The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.

There is an interesting overlap of function in a wide range of organisms between genes that modulate the stress responses and those that regulate aging phenotypes and, in some cases, lifespan. We have therefore screened mutagenized zebrafish embryos for the altered expression of a stress biomarker,...

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Main Authors: Shuji Kishi, Peter E Bayliss, Junzo Uchiyama, Eriko Koshimizu, Jie Qi, Purushothama Nanjappa, Shintaro Imamura, Asiful Islam, Donna Neuberg, Adam Amsterdam, Thomas M Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2515337?pdf=render