Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways

Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways

Purpose: Sepantronium bromide (YM155) is a Survivin inhibitor which recently advanced as an anticancer agent in phase II clinical trials. Survivin belongs to IAP (inhibitor of apoptosis) gene family and is a pivotal target for treatment due to its overexpression and oncogenic function in many malign...

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Bibliographic Details
Main Authors: Kobra Shojaei Moghadam, Majid Farshdousti Hagh, Mohammad Reza Alivand, Masoumeh Fardi, Ali Akbar Movassaghpour, Ali Mohammadi, Maryam Moghadasi, Saeed Solali
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-01-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
apoptosis
cancer
drug
survivin
molt-4
ym155
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-27892

Internet

https://apb.tbzmed.ac.ir/PDF/apb-27892

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