Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in the Developing Fetal Rat Heart by Sex-Specific Mechanisms

Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in the Developing Fetal Rat Heart by Sex-Specific Mechanisms

Infants born to diabetic or obese mothers are at greater risk of heart disease at birth and throughout life, but prevention is hindered because underlying mechanisms remain poorly understood. Using a rat model, we showed that prenatal exposure to maternal diabetes and a high-fat diet caused diastoli...

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Bibliographic Details
Main Authors: Tricia D. Larsen, Kyle H. Sabey, Alexis J. Knutson, Tyler C. T. Gandy, Eli J. Louwagie, Lothar Lauterboeck, Kennedy S. Mdaki, Michelle L. Baack
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
maternal diabetes
maternal high-fat diet
cardiovascular disease
mitochondrial dynamism
sex-specific mechanisms of the developmental origins of health and disease (DOHaD)
Online Access:https://www.mdpi.com/1422-0067/20/12/3090

Internet

https://www.mdpi.com/1422-0067/20/12/3090

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